Christina Applegate and Jamie-Lynn Sigler Open Up About Living with Multiple Sclerosis

Christina Applegate finds herself part of a sisterhood she never anticipated – one shaped by the shared journey of living with multiple sclerosis (MS). In a candid conversation on “Good Morning America” aired on Wednesday, the “Dead To Me” star, joined by her friend Jamie-Lynn Sigler, delved into their experiences navigating life with this autoimmune disease affecting the central nervous system.

Both Applegate and Sigler, known for their roles in various television shows and films, including “The Sweetest Thing,” disclosed their MS diagnoses. Applegate credited Selma Blair, her co-star in “The Sweetest Thing,” for encouraging her to seek medical attention, recognizing symptoms she initially dismissed.

Reflecting on her journey, Applegate acknowledged the pivotal role Blair played in her diagnosis, stating, “If not for her, it could have been way worse.” Applegate publicly disclosed her MS diagnosis in August 2021, realizing that she likely grappled with the condition for years before receiving an official diagnosis.

Finding solace and support in each other, Applegate and Sigler are now embarking on a new venture – a podcast titled “Messy.” Promising authentic conversations about the complexities of life with MS, the duo aims to shed light on the often overlooked aspects of living with the disease.

“I’ve been playing a character called Christina for 40 years,” Applegate shared, expressing her desire for authenticity and vulnerability in her journey with MS. Sigler echoed her sentiments, emphasizing her admiration for Applegate’s resilience and the beauty she sees in her unfolding story.

Kindly share this story: